A 31-year-old African American man presents to the emergency room and is diagnosed as having a…

A 31-year-old African American man presents to the emergency room and is diagnosed as having a community-acquired pneumonia. After 2 days of antibiotics, the patient becomes jaundiced. His hematocrit is 30% (decreased from 40% on admission), reticulocyte count is 6%, and indirect bilirubin value is 4.5 mg/dL (total bilirubin of 6.0 mg/dL). Peripheral blood smear demonstrates Heinz bodies. The patient recalls a similar problem when he was given antibiotics 5 years ago for an acute sinusitis. His three brothers have a similar reaction to antibiotics. Which of the following is the most likely diagnosis? a. Sickle cell anemia b. Sickle cell trait c. Autoimmune hemolytic anemia d. Glucose-6-phosphate dehydrogenase deficiency e. Allergic reaction

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